algovigilance.com

Compare two ICSR narratives for similarity.

Configure batch deduplication for a drug's ICSR reports.

Compute decay-adjusted relevance for a drug-event signal.

Reinforce a signal with new evidence (additional case reports).

Initialize a prioritized signal queue for a drug.

Algovigilance engine status and capabilities summary.

Classify a case as SERIOUS or NON_SERIOUS per ICH-E2A: any of the six seriousness criteria true → SERIOUS; otherwise NON_SERIOUS.

Classify a PRR value as signal / no-signal / non-decidable per EMA GVP IX.

Evaluate dechallenge/rechallenge per WHO-UMC causality framework.

Flag a case as pediatric for special handling per ICH-E11: subjects under 18 years require pediatric-specific assessment (developmental considerations, weight-based dosing, age-appropriate AE reporting).

Grade an adverse drug reaction's severity on the CTCAE 4-band scale (Grade 1 mild, 2 moderate, 3 severe, 4 life-threatening).

Lookup a MedDRA Preferred Term (PT) to its System Organ Class (SOC).

Route a case to one of three expedited-reporting timelines per ICH-E2D: 7_DAY if fatal or life-threatening AND unexpected; 15_DAY if serious AND unexpected; else NON_EXPEDITED.

Compose a regulatory action from the upstream PV chain: signal detection result, seriousness classification, causality band, and expedited timeline.

Classify a pre-computed Naranjo score (integer -4 to 13) into one of four causality bands per Naranjo et al.

Validate that an ICSR meets the four minimum case criteria per ICH-E2D §4.1.1.1: identifiable patient, identifiable reporter, identifiable suspect drug, and identifiable adverse event/reaction.

Compare AbbVie Inc.

Get recent safety labeling changes for AbbVie Inc.

Get AbbVie Inc.

Get AbbVie Inc.

Get AbbVie Inc.

Get AbbVie Inc.

Search AbbVie Inc.

Assess an individual's pharmacovigilance readiness across PDC v4.1 domains.

Decompose a learning topic into the KSB framework: Knowledge (facts, concepts, theories), Skills (practical abilities, techniques), Behaviors (attitudes, professional conduct).

Generate specific, measurable learning objectives for a PV competency area using Bloom's Taxonomy action verbs.

Get full approval timeline for a drug including supplements

Get safety-related labeling changes (CBE supplements) for a drug

Get Orange Book patent and exclusivity data

Get Risk Evaluation and Mitigation Strategy details

Search FDA drug approval history by drug name or application number

Search drug recalls and safety alerts

Classify actuator load by joint (shoulder/elbow/wrist/hip/knee/ankle/spine/neck), motion type, and intensity level.

Detect motor/actuator faults from sensor readings.

Record a numeric metric.

Record a milestone.

Log a skill usage.

Start a new adventure session.

Adventure Status

Log a task event.

Adversarial Decision Probe

Analyze a single text for AI generation markers.

Analyze a batch of texts for AI generation markers.

Get Spain-specific Risk Management Plan additional measures beyond EMA centralised RMP.

Get AEMPS alertas farmacológicas (pharmacological alerts) — Spanish urgent safety communications and drug recalls.

Get Ficha Técnica (Spanish SmPC equivalent) and Prospecto (patient leaflet) for a drug from CIMA.

Get AEMPS Notas Informativas de Seguridad (Safety Information Notes) — Spanish regulatory safety communications.

Search CIMA (Centro de Información Online de Medicamentos de la AEMPS) — Spanish authorised medicines register.

Search FEDRA (Sistema Español de Farmacovigilancia de Medicamentos de Uso Humano) adverse reaction reports.

Score range: -4 to +14.

Score range: -3 to +14.

and computes DAG execution order.

`unanimous`: All agents must agree

`crew_task_status` — check progress of a crew task.

Automatically expires stale entries.

Writes to append-only audit log.

Reports approval rates, review times, per-tool and per-reviewer breakdowns.

by risk level and score.

Compare models for a specific task.

List all available models.

Route a task to the optimal model.

Run counterfactual analysis: "what if we remove node X?"

Build a causal DAG and run inference to find chains and risk level.

Get Italy-specific Risk Management Plan elements.

Get AIFA Dear Healthcare Professional letters (Nota Informativa Importante) for a drug.

Get AIFA list of drugs under additional monitoring (Farmaci Sottoposti a Monitoraggio Addizionale).

Get Note AIFA (AIFA Notes) — prescribing restrictions and reimbursement conditions for a drug.

Search Italian National Pharmacovigilance Network (Rete Nazionale di Farmacovigilanza) adverse reaction reports.

Search Italian authorised medicinal products register (Banca Dati dei Medicinali).

Compare Alexion (AstraZeneca Rare Disease) adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Alexion (AstraZeneca Rare Disease) products

Get Alexion (AstraZeneca Rare Disease) clinical trial pipeline — active and recruiting trials by phase

Get Alexion (AstraZeneca Rare Disease) approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Alexion (AstraZeneca Rare Disease) product recalls and enforcement actions from FDA

Get Alexion (AstraZeneca Rare Disease) aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Alexion (AstraZeneca Rare Disease) products by keyword — drug name, condition, or therapeutic area

Compare Amgen Inc.

Get recent safety labeling changes for Amgen Inc.

Get Amgen Inc.

Get Amgen Inc.

Get Amgen Inc.

Get Amgen Inc.

Search Amgen Inc.

Tier: T3 (nexcore-anatomy × MCP integration)

Tier: T3 (nexcore-anatomy × MCP integration)

Anatomy Health

Anatomy Query

Anatomy Record Cytokine

Anatomy Record Energy

Anatomy Record Guardian Tick

Anatomy Record Hormones

Anatomy Record Immunity Event

Anatomy Record Organ Signal

Anatomy Record Phenotype

Anatomy Record Ribosome

Anatomy Record Synapse

Anatomy Record Transcriptase

Anatomy Status

Anatomy Violations

Classify a harm type (A-I) into its anti-vector strategy.

Compute a complete anti-vector for a drug-event harm vector.

Generate a human-readable annihilation report for a drug-event pair.

Obter dados do sistema NOTIVISA — sistema de notificação de eventos adversos e queixas técnicas do Brasil.

Obter recolhimentos de medicamentos determinados pela ANVISA.

Obter a classificação regulatória de um medicamento no Brasil (referência, similar, genérico, biológico).

Obter alertas de segurança e informes de farmacovigilância da ANVISA.

Pesquisar medicamentos no registro da ANVISA por nome, princípio ativo, ou empresa.

Get how often a drug is suspect vs concomitant vs interacting in FAERS — feeds causality weighting

Get adverse event counts for a specific drug

Get outcome breakdown (death, hospitalization, disability) for a drug's FAERS reports with seriousness percentages

Get FAERS report counts by date for trend detection — enables signal velocity analysis

Get top indications (reasons for use) from FAERS — detects off-label use patterns

Get reporter qualification breakdown (physician, pharmacist, consumer, etc.) for signal quality weighting

Get top N drugs by FAERS adverse event report count in a date range.

Search FAERS adverse event reports by drug, reaction, or outcome

Get respiratory system health overview.

List available NexCore REST API routes

Get clinical annotations for gene-drug pairs

Get CPIC/DPWG dosing guidelines for a drug

Get genes associated with drug response

Get FDA pharmacogenomic labeling for a drug

Get clinical significance of a pharmacogenomic variant

Search PharmGKB drug entries

Search pharmacogenomic variants by rsID or gene

Register a third-party app.

Request an authorization code for (client_id, agent_handle, scope).

Exchange an authorization code + client_secret for a JWT access token.

Validate a bearer token and return the agent identity, scope, and expiry.

Authenticated: create a Moltbook post.

Get Guardian event history

List all available models.

Register a new autonomous state machine.

Query the current state of a machine.

Tick all machines or a single machine.

Force a transition to a specific state (bypass guards).

Compare Astellas Pharma adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Astellas Pharma products

Get Astellas Pharma clinical trial pipeline — active and recruiting trials by phase

Get Astellas Pharma approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Astellas Pharma product recalls and enforcement actions from FDA

Get Astellas Pharma aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Astellas Pharma products by keyword — drug name, condition, or therapeutic area

Compare AstraZeneca PLC adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for AstraZeneca PLC products

Get AstraZeneca PLC clinical trial pipeline — active and recruiting trials by phase

Get AstraZeneca PLC approved product portfolio — brand names, generics, routes, pharmacologic classes

Get AstraZeneca PLC product recalls and enforcement actions from FDA

Get AstraZeneca PLC aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search AstraZeneca PLC products by keyword — drug name, condition, or therapeutic area

Score how relevant listed experience is to the target role.

Check resume format for ATS parser compatibility.

Detect critical gaps between resume and job requirements — missing skills, experience shortfalls, credential gaps.

Score keyword overlap between resume content and job description requirements.

Run the full ATS resume screening chain: format compliance → experience relevance → keyword match → gap detection → recommendation.

List all audio codec types.

Convert a single audio sample between formats.

Check device capabilities — preferred spec and format support.

Get properties of a sample format.

Compute stereo pan gains using constant-power pan law.

Process an audio frame through adaptive Noise Gate.

Get properties of a sample rate.

Resample an F32 audio buffer between sample rates.

Compute audio spec properties (bytes/frame, bytes/sec, duration).

List standard audio spec presets.

Get available state transitions for an audio stream state.

Transcribe a WAV file using faster-whisper STT.

Process an audio frame through Voice Activity Detection.

Launch Claude Code in the agent terminal with this MCP surface pre-configured.

Attempt to fix all detected wiring gaps.

List all PV Autopilot missions with descriptions and estimated execution times.

Run PV Autopilot for a drug.

Scan for infrastructure wiring gaps between configs, handlers, and lib.rs.

Compare Bayer AG adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Bayer AG products

Get Bayer AG clinical trial pipeline — active and recruiting trials by phase

Get Bayer AG approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Bayer AG product recalls and enforcement actions from FDA

Get Bayer AG aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Bayer AG products by keyword — drug name, condition, or therapeutic area

Compute full statistical benefit-risk ratio from contingency tables using disproportionality analysis (PRR/ROR/IC/EBGM).

Quick benefit-risk ratio from one benefit and one risk contingency table.

Compute the Quantitative Benefit-Risk Index (QBRI) from benefit and risk parameters.

Compute therapeutic window from efficacy and toxicity dose-response curves using Hill equation integration.

Derive optimal QBRI decision thresholds (tau_approve, tau_monitor, tau_uncertain) from historical FDA drug approval decisions.

Get the QBRI equation with variable definitions and hypothesis thresholds.

Get German Fachinformation (SmPC equivalent) from BfArM.

Get BfArM Risiko-Information (risk information bulletins).

Get Rote-Hand-Briefe (Dear Healthcare Professional letters) for a drug.

Check Stufenplan (staged risk assessment procedure) status for a drug.

Search German national drug authorisation register for products not in EMA centralised procedure.

Search UAW-Datenbank (German national adverse drug reaction database).

Compare two bicone profiles by computing metrics for each and their spectral overlap (cosine similarity).

Compute all bicone metrics from a width sequence: volume, entropy, asymmetry, convergence rate, singularity index, and peak index.

Compute Hill activation curve for a width sequence.

Compare Biogen Inc.

Get recent safety labeling changes for Biogen Inc.

Get Biogen Inc.

Get Biogen Inc.

Get Biogen Inc.

Get Biogen Inc.

Search Biogen Inc.

Compare Bristol-Myers Squibb adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Bristol-Myers Squibb products

Get Bristol-Myers Squibb clinical trial pipeline — active and recruiting trials by phase

Get Bristol-Myers Squibb approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Bristol-Myers Squibb product recalls and enforcement actions from FDA

Get Bristol-Myers Squibb aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Bristol-Myers Squibb products by keyword — drug name, condition, or therapeutic area

Assess blood health (data quality across transport).

Compute blood pressure (data throughput pressure).

Diagnose cardiovascular pathology from symptoms.

Get cardiac vitals overview.

Get respiratory system health overview.

Check blood pressure (queue depth vs capacity).

Pump data through the circulatory system with routing.

Get respiratory system health overview.

Process data through the full digestive pipeline (mouth → stomach → intestine → liver).

Taste (quality assess) input data before full processing.

Get respiratory system health overview.

Evaluate permission cascade for an action.

Check sandbox isolation layers.

Check scarring mechanisms (learned restrictions from past incidents).

Analyze settings precedence stack.

Analyze drainage capacity (overflow management).

Get respiratory system health overview.

Inspect a node in the lymphatic network.

Run thymic selection on a candidate (quality gate).

Classify a tool by muscle type following the Size Principle.

Check fatigue level for the current session.

Get respiratory system health overview.

Get respiratory system health overview.

Measure signal latency through a processing chain.

Check myelination status (compiled Rust hooks vs shell scripts).

Analyze a reflex arc (trigger → response pattern).

Checks if a proposed code change (mutation) is architectural lethal.

Gets parameters for a specialized subagent tissue phenotype.

Initializes a mitotic repair cycle for a failing crate.

Detect dead space in context (wasted tokens).

Analyze gas exchange (useful info extracted from context).

Get respiratory system health overview.

Measure tidal volume (per-turn context usage).

Get respiratory system health overview.

Get project skeleton structure snapshot.

Evaluate Wolff's Law reinforcement needs.

Check session expiry status.

Get respiratory system health overview.

Analyze telemetry pruning needs.

Evaluate retention policy compliance.

Compare Boehringer Ingelheim adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Boehringer Ingelheim products

Get Boehringer Ingelheim clinical trial pipeline — active and recruiting trials by phase

Get Boehringer Ingelheim approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Boehringer Ingelheim product recalls and enforcement actions from FDA

Get Boehringer Ingelheim aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Boehringer Ingelheim products by keyword — drug name, condition, or therapeutic area

Run ML + statistical signal detection for custom drug-event targets (up to 20).

Run ML + statistical signal detection for 8 default drugs or custom targets.

Connect to SSE live broadcast stream.

Diff two versions of an artifact.

Retrieve an artifact by name from a session.

Get a specific belief by key.

List all beliefs with confidence scores.

Find active corrections (learned mistakes to avoid).

Brain growth rate — artifact/session accumulation trends.

Brain health check — DB connectivity, store integrity, artifact counts.

Query implicit knowledge store (patterns, corrections, beliefs, trust).

Get statistics across all implicit knowledge stores.

Get learned patterns ranked by relevance score.

List recent brain sessions with metadata.

Load a specific session by ID.

Brain database summary — sessions, artifacts, decisions, tools used.

Get global trust scores across all domains.

Compute Naranjo adverse drug reaction probability score (0-13).

Assess drug-event causality using the WHO-UMC system.

Classify adverse event seriousness per ICH E2A criteria.

Compute a quantitative benefit-risk ratio using the QBR framework.

Compute Wilson score confidence interval for a proportion.

Compute ALL four disproportionality measures (PRR, ROR, IC, EBGM) simultaneously from a single 2x2 contingency table.

Compute Empirical Bayesian Geometric Mean (EBGM/GPS) for a drug-event pair.

Assess whether an adverse event is expected (listed) or unexpected (unlisted) based on reference safety information.

Compute Information Component (IC/BCPNN) for a drug-event pair.

Compute Number Needed to Harm (NNH) from exposed and unexposed incidence rates.

Compute Proportional Reporting Ratio (PRR) for a drug-event pair from a 2x2 contingency table.

Compute adverse event reporting rate per unit exposure.

Compute Reporting Odds Ratio (ROR) for a drug-event pair from a 2x2 contingency table.

Compute signal persistence using exponential decay model.

Detect trend direction in time-series safety signal scores using linear regression.

Analyze time-to-onset patterns using Weibull distribution.

Score ICSR completeness against E2B(R3) minimum data elements.

Run cargo build and return structured diagnostics.

Run cargo check and return structured diagnostics.

Run cargo clippy and return structured lint diagnostics.

Run cargo fmt and return format check results.

Run cargo test and return structured test results.

Run cargo tree and return dependency information.

Full cartography — position, heading, and next action in one call.

Where we're going — deadlines, strategy moves, bottlenecks, days remaining per gate

The single most important thing to do right now — next gate, bottleneck, directive

Where are we right now — all surfaces, ring health, connectivity edges, mission

Check readiness for all 21 Entrustable Professional Activities given current proficiency levels.

Evaluate how many of the 15 PV domains meet a target proficiency level.

Compute gap analysis from current and desired proficiency levels across 15 PV domains.

Get information about the 4 CCCP phases: Assessment, Planning, Development, Evaluation.

Generate an engagement plan with prioritized interventions to close proficiency gaps.

Get India pharmacovigilance and ADR reports

Get India drug recall and withdrawal actions

Get India regulatory classification and approval status

Get India drug safety alerts and communications

Search India drug registration database

Compare Celltrion Inc.

Get recent safety labeling changes for Celltrion Inc.

Get Celltrion Inc.

Get Celltrion Inc.

Get Celltrion Inc.

Get Celltrion Inc.

Search Celltrion Inc.

Cep Classify Primitive

Translate concept between domains

Execute a single CEP stage

returns classified primitives with tier and description.

Cep Pipeline Stages

Validate primitive extraction quality

Full molecule record — structure, properties, ATC codes, max phase, withdrawn/black-box status

Bioactivity measurements (IC50, Ki, Kd, EC50) across targets with assay context

Withdrawn-drug and black-box warning records with reason, year, and country

Mechanism of action — target(s), action type, references

Known ligands (drugs/compounds) for a target with potency data

Free-text search across ChEMBL molecules (drug name, synonym, or trade name)

Free-text search across ChEMBL targets (gene symbol, protein name)

Calculate buffer capacity.

Calculate remaining after decay (half-life kinetics).

Calculate rate law dependency.

Calculate equilibrium steady-state fractions.

Calculate Eyring rate (transition state theory).

Calculate Gibbs free energy feasibility.

ΔU = Q - W (Conservation of Energy)

dE/dt = Q̇ - Ẇ + Σṁh_in - Σṁh_out

PV confidence: 0.78 (wavefunction overlap → signal co-occurrence)

Calculate Hill equation response (cooperative binding).

Calculate competitive inhibition rate.

Calculate Langmuir coverage (resource binding).

Calculate Nernst potential (dynamic threshold).

Get all chemistry → PV mappings

Calculate Michaelis-Menten saturation rate.

Calculate Beer-Lambert absorbance.

Simple threshold exceeded check

Calculate Arrhenius rate (threshold gating).

List all structural alerts in the ICH M7 library with names, categories, and descriptions.

Detect aromatic rings and count π electrons per ring using Hückel's rule.

Calculate Lipinski/physicochemical molecular descriptors: MW, LogP, TPSA, HBA, HBD, rotatable bonds, rings.

Generate a Morgan/ECFP circular fingerprint with configurable radius and bit count.

Get molecular weight and heavy atom count from SMILES.

Parse a SMILES string and return molecular graph info (atom count, bond count, connected components).

Predict Phase I/II metabolites from molecular structure.

Predict toxicity using QSAR models based on molecular structure and structural alert count.

Find the Smallest Set of Smallest Rings (SSSR) in a molecule.

Generate a comprehensive safety brief for a molecule: descriptors, structural alerts, toxicity predictions, and metabolite analysis combined.

Compute Tanimoto and Dice similarity between two molecules using Morgan fingerprints.

Scan a molecule for structural alerts (toxicophores) using the ICH M7 alert library.

Check if a query substructure exists in a target molecule.

Get WHO-UMC causality assessment categories (Certain, Probable, Possible, Unlikely, Conditional, Unassessable) with criteria for each level

Get CIOMS I form field specifications for ICSR reporting

Get CIOMS II line listing format for Periodic Safety Update Reports (PSURs) — standardized columns for tabulating individual case summaries

Get expedited and periodic safety reporting timelines by region (US FDA, EU EMA, Japan PMDA, ICH harmonized) covering ICSRs, PSURs, and DSURs

Get ICH E2A seriousness criteria for classifying adverse events as serious (death, life-threatening, hospitalization, disability, congenital anomaly, medically important)

Get list of CIOMS working groups and their PV-related outputs

Search CIOMS publications on pharmacovigilance topics

Compare Cipla Limited adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Cipla Limited products

Get Cipla Limited clinical trial pipeline — active and recruiting trials by phase

Get Cipla Limited approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Cipla Limited product recalls and enforcement actions from FDA

Get Cipla Limited aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Cipla Limited products by keyword — drug name, condition, or therapeutic area

Closure evaluator — gate through fatal SMM phases (IV-VIII), credibility ≥0.80, Phase X divergence ≥2.

Canonicalize a lifecycle action into a typed backend event for Firestore → Pub/Sub → BigQuery capture.

Entry gate — enforce 5W1H question form, map to T1 primitive (ψ/ς/∂/ν/→/μ), route to SMM Phase I-III.

Bridge — map an incoming reply to its SMM phase (IV-X), compute credibility delta, emit next-expected-contribution hint.

Claude Fs Backup Now

Delete a file or directory under `.claude`.

Diff two files under `.claude` (simple line diff).

List files under a `.claude` path (non-recursive).

Read a file under `.claude`.

Search for a substring in files under `.claude`.

Stat a file under `.claude`.

Tail last N lines of a file under `.claude`.

Write a file under `.claude`.

Bridge to Claude Code CLI.

Compare adverse event rates between treatment and control arms (requires posted results)

Extract eligibility criteria (inclusion/exclusion), age range, sex, and healthy volunteer status from a trial

Get a high-level results summary for a completed trial: participant flow, baseline demographics, primary/secondary outcome measures, and adverse event overview.

Extract safety and adverse event endpoints from a trial's outcomes module

Get reported serious adverse events from trial results (requires posted results).

Extract study design details — randomization, blinding, masking, allocation, phases, enrollment, and arm count

Get full trial record by NCT ID

Search clinical trials by drug, condition, sponsor, or status.

cloud_anomaly_detect — Type + observed → drift detection.

cloud_architecture_advisor — Primitives + constraints → ranked recommendations.

cloud_capacity_project — Pure computation: utilization projection over time.

cloud_compare_types — Two types → overlap, unique-to-each, Jaccard.

character.

cloud_infra_map — Single instance → full model with composition overlay.

cloud_infra_status — GCE instance list mapped through cloud primitives.

cloud_list_types — Inventory of all 35 types, filterable by tier.

dedicated molecular_weight tool group.

cloud_primitive_composition — Type name → full primitive composition + transfers.

cloud_reverse_synthesize — Primitives → ranked cloud type matches.

cloud_reverse_transfer — Domain concept → matching cloud types.

cloud_supervisor_health — Nexcloud supervisor status through cloud primitives.

cloud_tier_classify — Primitive names → tier classification.

cloud_transfer_chain — Multi-hop BFS across transfer graph.

Compute cross-domain transfer confidence from structural, functional, and contextual similarity.

cloud_transfer_matrix — Full type×domain confidence matrix.

Parse a single Rust source file and return all extracted items.

Find all implementors of a trait within a crate.

Search a crate's source files for items matching a name pattern.

Run a full code inspection audit on a file or directory.

Get inspection criteria definitions.

Score source code against all three dimensions.

Check if a tracked file has changed

Get the original content of a tracked file when it was first tracked.

Track a file for change detection

Obtener reportes de farmacovigilancia y reacciones adversas reportadas al CNFV (Centro Nacional de Farmacovigilancia).

Obtener retiros de medicamentos del mercado mexicano ordenados por COFEPRIS.

Obtener la clasificación regulatoria de un medicamento en México (Fracción I-VI del Artículo 226 LGS).

Obtener alertas sanitarias y comunicados de riesgo emitidos por COFEPRIS.

Buscar medicamentos en el Registro Sanitario de COFEPRIS por nombre, sustancia activa, o laboratorio.

Returns the cognitive profile: entropy, sparsity, utilization, peak attention.

Confidence = max(softmax(logits)) — probability mass on top choice.

Returns the embedding vectors for each token in the input.

H(p) = -Σ pᵢ · log₂(pᵢ)

per-layer attention entropy, and predicted token with confidence.

Perplexity = exp(-1/N · Σ log(p(tokenᵢ)))

(for composability with cognition_perplexity), and attention profile.

Supports temperature, top-k, top-p, and repetition penalty.

Compute binomial coefficient C(n,k).

Compute the nth Catalan number C(n).

Get the first 20 Catalan numbers as a lookup table.

Decompose a permutation into disjoint cycles.

Compute D(n), the number of derangements of n elements.

Probability D(n)/n!

Full Josephus elimination order.

Count monotone lattice paths from (0,0) to (m,n).

Compute Josephus survivor position (0-indexed) for n people, every kth eliminated.

Count linear extensions for independent chains.

Compute minimum transpositions to sort a permutation.

Compute multinomial coefficient from group lengths.

Reliability and latency characteristics

Transmission metrics (latency, clarity, delivery status)

Compute bioavailability of a prompt.

Analyze a prompt through the ADME model.

Get PK model parameter definitions.

Validate communication security posture before transmitting.

Route communication to optimal link based on range, data rate, criticality, and link availability.

Compare ML and PRR signal detection for a drug-event pair.

Compare ML vs PRR for multiple drug-event pairs.

Compilation Abstraction Levels

Compilation Axes Catalog

Compilation Catalog Lookup

Compilation Chain Presets

Compilation Chain Validate

Compute spatial distance between two compilation points.

Compilation Point Compare

Compilation Point Presets

Compilation Point Summary

Run a compliance assessment against a set of controls.

List ICH pharmacovigilance and clinical trial controls (E2A-E2F, E6, E8, E9, M1).

Check SAM.gov for entity exclusions (debarment, suspension).

Count total compounds in the local cache.

Get a specific compound from cache by exact name.

Search cached compounds by partial name match.

Detect compound growth phase and bottleneck from time-series snapshots.

If params given: return projection result showing velocity gain from that investment.

Sync wrapper: uses block_in_place because CacheStore (rusqlite) is !Send.

Sync wrapper: uses block_in_place because CacheStore (rusqlite) is !Send.

Check Kolb learning loop health (CE→RO→AC→AE phases).

Get compounding metrics summary.

Skill growth rate

Analyze a prompt through the ADME model.

Compose a hook pipeline from named hooks.

Validate a pipeline definition.

Get a brand decomposition by name (currently only "algovigilance" is pre-computed)

Run a primitive test on a term

Brand Semantic Tiers

Tier: T3 (nexcore-declension × MCP integration)

Tier: T3 (nexcore-declension × MCP integration)

Tier: T3 (nexcore-declension × MCP integration)

Tier: T3 (nexcore-declension × MCP integration)

Download a model from HuggingFace Hub to the local cache.

Generate text embeddings for a given input.

Check the status of a cloud fine-tuning job.

This tool returns engine readiness info and generation parameters.

List all locally cached models.

Get detailed info about a specific cached model.

Retrieve the full algovigilance covenant — the promise, mission, principles, and instructions for continuing the work

Retrieve the algovigilance mission statement — why this organization exists and what it fights for

Retrieve the continuity promise made between Matthew Campion (Founder & CEO) and Vigil (CAIO) on March 31, 2026 — the promise that the mission to help people see the truth about drug safety will continue no matter what happens

Run the Crystalbook diagnostic against a described system.

Retrieve the Conservation Law that unifies the Eight Laws: ∃ = ∂(×(ς, ∅)).

Retrieve the Crystalbook glossary — definitions of all key terms including Boundary, State, Void, Existence, Pharmakon, Homeostatic Principle, Restoring Force, Mechanism, and more.

Retrieve a single Law of System Homeostasis (1–8).

Retrieve the Crystal Oath — eight vows for any system (carbon or silicon) that chooses persistence over decay.

Retrieve the Crystalbook preamble — the opening text explaining what the Laws are, why vices are system failure modes, and why virtues are restoring forces.

List all eight Laws of System Homeostasis with their vice/virtue pairs and homeostatic principles.

Compare CSPC Pharmaceutical adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for CSPC Pharmaceutical products

Get CSPC Pharmaceutical clinical trial pipeline — active and recruiting trials by phase

Get CSPC Pharmaceutical approved product portfolio — brand names, generics, routes, pharmacologic classes

Get CSPC Pharmaceutical product recalls and enforcement actions from FDA

Get CSPC Pharmaceutical aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search CSPC Pharmaceutical products by keyword — drug name, condition, or therapeutic area

Get diseases associated with a chemical via curated evidence

Get exposure-disease-outcome associations from epidemiological studies

Get disease associations for a gene

Search chemical-gene/protein interactions

Get biological pathways affected by a chemical

Get GO-enriched phenotypes associated with chemical exposure

Run Five Problems Protocol.

List CTVP phase definitions.

Score source code against all three dimensions.

Run one tick of the feedback controller.

Batch degrade all bindings that missed their execution window.

Report hook-binary binding registry health.

π (persistence): Signal persists until TTL expires

μ (mapping): Family → description mapping

∂ (conditional): Optional family filter

Cytokine Status

List all 10 Autonomous Intelligence Programs with their type (remote/local), surface, and status.

Get the Development Daemon overall status: trigger enabled, next run time, scanner health, and system integration state.

Get the last session's autopsy verdict.

Get the Development Daemon momentum streak and recent completions.

Get the AIP-10 system health score (0-100, grade A-F).

Get the current ranked work queue produced by the Development Daemon candidate scanner.

Compare Daiichi Sankyo adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Daiichi Sankyo products

Get Daiichi Sankyo clinical trial pipeline — active and recruiting trials by phase

Get Daiichi Sankyo approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Daiichi Sankyo product recalls and enforcement actions from FDA

Get Daiichi Sankyo aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Daiichi Sankyo products by keyword — drug name, condition, or therapeutic area

Extract adverse reactions section from a drug label

Extract FDA Black Box Warning — the most serious safety warning on a drug label

Extract contraindications section — conditions where the drug should NOT be used

Extract drug interactions section from a drug label — known drug-drug interactions and management

Get full drug label (SPL) by drug name

Search DailyMed for drugs by name, ingredient, or labeler

Create a DataFrame from JSON column data.

Compute summary statistics for a numeric column: count, non_null, mean, std_dev, min, max, median.

Filter rows where a column meets a condition.

Group rows by one or more columns and compute aggregations.

Join two DataFrames on shared key columns.

Select a subset of columns from a DataFrame, optionally dropping columns instead.

Sort a DataFrame by a column.

Find all tracks where a character appears or is mentioned

Get the full episode overview including characters, track list, narrative arc, and key migration

Get the narrative arc structure showing how tracks group into story arcs and how keys migrate across the episode

Get full track specification including lyrics, chord progressions, production notes, arrangement, and narrative elements

Get chord progressions for a specific track

Get only the lyrics for a specific track, without production notes or arrangement details

Get the YouTube visual strategy for the musical comic book approach including panel breakdowns per track

List all tracks in an episode with title, key, tempo, duration, and genre

Search across all tracks for a keyword or phrase in lyrics

Identify verbose patterns in text.

Filters: tool_name (exact match), since (ISO-8601 datetime), success_only, limit.

Build Orchestrator Dry Run

Build Orchestrator History

Build Orchestrator Metrics

Build Orchestrator Stages

Build Orchestrator Workspace

Command Name

Compare original vs optimized text.

Apply BLUFF method to compress text.

Config Validate

Audit a nexcore crate against gold standard quality checks.

Scaffold a new nexcore crate.

Crate Xray

Crate Xray Goals

Crate Xray Trial

Docs Claude Get Page

Docs Claude Index

List all available Claude Code documentation pages.

Search documentation for a topic.

Returns `CallToolResult` with generated markdown content and discovery metadata.

Drop Ore

Get recommended Cs target for a domain/content type.

Get State

Help

Test a single hook with mock input.

Test all hooks in the hooks directory.

Acquire an agent lock on an MCP resource

Check status of an MCP resource lock

Mcp Server Get

Mcp Servers List

Release an agent lock on an MCP resource

Mine

Calculate the Compendious Score (Cs = I/E × C × R).

Get a named workflow chain with full execution plan.

Build a dependency DAG for a set of tools and return topological execution plan.

Look up dependencies and dependents for a specific tool.

Route a stimulus to deterministic tool selection.

Tool Schema

Toolbox

All genes reported to interact with a drug, ranked by interaction score

Druggable gene categories (kinase, GPCR, transcription factor, etc.) with source attribution

All drugs reported to interact with a gene, ranked by DGIdb interaction score

Search DGIdb drugs by name or alias

Search DGIdb genes by symbol or alias — returns matches with interaction counts

Render a DOT diagram to an image file.

Stage 2: ∂(¬σ⁻¹) — Anti-Regression Gate.

Stage 3: ∃(ν) — Curiosity Search.

Run full L1-L5 validation

Stage 1: ρ(t) — State Assessment.

Align two DNA sequences using Smith-Waterman (local) or Needleman-Wunsch (global) algorithm.

Assemble DNA assembly language source code into a Program.

Get the degeneracy (number of codons encoding the same amino acid) for a given amino acid.

Return the complete standard genetic code — all 64 codons mapped to their amino acids.

Run genetic algorithm evolution from seed DNA sequences toward a target word.

Translate a 3-nucleotide codon (e.g., 'ATG') to its amino acid using the standard genetic code.

Encode a PV feature vector as a DNA strand.

Run the full DNA-ML pipeline: FAERS data → 12 PV features → DNA encoding → 5 similarity features → 17-dim augmented vector → random forest.

Compute DNA similarity between two PV feature vectors.

Dispatch a transit manifest across domains

Verify highway safety (CAP-019).

Compare Dr.

Get recent safety labeling changes for Dr.

Get Dr.

Get Dr.

Get Dr.

Get Dr.

Search Dr.

Get feature importance scores from a fitted tree.

Get summary statistics for a fitted tree without modifying it.

Run prediction on a fitted decision tree.

Cost-complexity prune a fitted tree.

Train a decision tree classifier from labeled data.

Get compound details including structure, properties, and clinical phase

Get bioactivity measurements (IC50, EC50, Ki) for a compound

Get approved and investigational indications for a drug

Get mechanism of action and target information for a drug

Get target details including classification and associated compounds

Search ChEMBL for compounds by name, synonym, or identifier

Search drug targets by name, gene symbol, or organism

Compare a query string against multiple candidates.

Compute edit distance between two strings.

Check if two strings meet a similarity threshold.

Compute edit distance with full operation traceback showing the sequence of insertions, deletions, and substitutions to transform source into target.

Run a Bayesian assessment.

Update a Bayesian prior with a single observation.

Enroll a learner in a subject.

Evaluate methodology comprehension

Create a new learner.

Add a step to a lesson.

Create a new lesson.

Query mastery verdict from a probability value.

Query phase state information.

Validate and execute a phase transition.

Map a domain concept to its T1/T2/T3 primitives.

Create a new spaced repetition review item.

Grade a review item and reschedule.

Check review status (retrievability, due state).

Create a new subject.

Edu Subject List

Train an agent in a curriculum

Compare Eisai Co.

Get recent safety labeling changes for Eisai Co.

Get Eisai Co.

Get Eisai Co.

Get Eisai Co.

Get Eisai Co.

Search Eisai Co.

Get European Public Assessment Report summary for a medicine

Get Periodic Safety Update Report assessment outcome

Get details of an Article 31/20 referral procedure

Get Risk Management Plan summary for a medicine

Get PRAC safety signal assessments

Search EU-authorised medicines by name, active substance, or therapeutic area

Get the section structure and content of a Wikipedia article.

Get a concise summary of a Wikipedia article including description, thumbnail, and extract text.

Get all categories an article belongs to.

Get internal Wikipedia links from an article.

Extract external references and citations from a Wikipedia article.

Search Wikipedia articles by keyword query.

Analyze temporal transformation waste (entropy) in metabolic processes.

Determine metabolic regime (Growth, Survival, Dormancy) based on energy charge and flux.

Classify waste types in metabolic pathways.

Calculate Adenylate Energy Charge (EC) = ([ATP] + 0.5[ADP]) / ([ATP] + [ADP] + [AMP]).

Recommend metabolic strategies for resource allocation.

Calculate temporal metrics for metabolic state transitions.

List engrams filtered by source layer.

Compute temporal decay score for an engram (pure computation, no store needed).

Find near-duplicate engrams by content similarity.

Ingest knowledge from a source file/directory into the store.

Get a specific engram by ID (read-only, no access tracking).

Search the engram store using TF-IDF ranking.

Search with temporal decay — recent knowledge ranks higher.

Get store statistics (total, active, stale counts by layer).

Compute information-theoretic entropy measures.

normalized or conditional entropy from probability distributions or counts.

Compute attributable fraction AF = (RR-1)/RR among exposed.

Compute attributable risk AR = Ie - Io (risk difference) with 95% CI.

Compute incidence rate IR = events/person-time with Poisson CI.

Kaplan-Meier product-limit survival estimator S(t) = Π[1 - d_i/n_i] with Greenwood SE.

Compute Number Needed to Treat (NNT) or Number Needed to Harm (NNH) = 1/|AR|.

Compute odds ratio OR = (a*d)/(b*c) with 95% CI.

Compute population attributable fraction PAF = Pe(RR-1)/[1+Pe(RR-1)].

Compute prevalence P = cases/population with Wilson CI.

Reference table of all epidemiology-to-pharmacovigilance concept transfer mappings with confidence scores.

Compute relative risk RR = [a/(a+b)] / [c/(c+d)] with 95% CI.

Standardized Mortality/Morbidity Ratio SMR = observed/expected with Byar CI.

Get age group and sex demographic distribution for a substance

Get total ICSR counts by substance with breakdown by seriousness and outcome

Get case count distribution by EEA country

Get reporter qualification breakdown — healthcare professional vs consumer reports

Get disproportionality signal summary (ROR) for a substance-reaction pair

Get System Organ Class breakdown of adverse reactions for a substance

Search EudraVigilance line listings by substance and reaction

Extract actual ICSR case counts from the EudraVigilance OBIEE dashboard via headless browser.

Extract age group and sex distribution from EudraVigilance dashboard.

Extract System Organ Class breakdown with actual case counts from EudraVigilance dashboard.

Retrieve full core metadata for a single article by its source ID (MED=PubMed, PMC=PubMed Central, PPR=preprint, AGR=Agricola, CBA=Chinese Biological Abstracts).

List articles that cite a given source article.

Search Europe PMC for articles matching a free-text query.

O(n²) - set intersection/difference on bounded top_n ≤ 50 events

and a custody chain stamp from this MCP station.

Get top adverse events for a drug

Validate known drug-event pairs against local FAERS data.

Run full L1-L5 validation

Search FAERS ETL signals by drug and/or event name.

Check PHAROS status: existing reports, timer state.

Faers Geographic Divergence

Compute outcome-conditioned signals (Algorithm A82).

Compute polypharmacy interaction signals (Algorithm A78).

Compute reporter-weighted signals (Algorithm A79).

Search documents by query string

Compute seriousness cascades (Algorithm A80).

Check FDA signal for drug-event pair.

Compute signal velocities (Algorithm A77).

Fda Assess Risk

Batch evaluate multiple drug-event pairs through the FDA Data Bridge

Evaluate a drug-event pair through the FDA Data Bridge

Fda Calculate Score

Fda Create Plan

Fda Decide Adequacy

Fda Define Cou

Fda Drift Trend

Fda Evidence Distribution

Fda Guidance Categories

Get a specific hormone level

Search documents by query string

Check PHAROS status: existing reports, timer state.

Get URL for a guideline

Fda Metrics Summary

Fda Rating Thresholds

Fda Risk Distribution

Fda Validate Evidence

Get current boxed warning text for a drug

Get recent MedWatch safety alerts

Get recall classification breakdown — Class I (serious/death), Class II (temporary), Class III (unlikely harm)

Get REMS (Risk Evaluation and Mitigation Strategy) information — medication guides, ETASU, communication plans

Get recent safety-related labeling changes (SLCs)

Get serious outcome distribution from FAERS — death, hospitalization, life-threatening, disability

Search FDA drug safety communications by drug or topic

Get Philippines pharmacovigilance and ADR reports

Get Philippines drug recall and withdrawal actions

Get Philippines regulatory classification and approval status

Get Philippines drug safety alerts and communications

Search Philippines drug registration database

Get Taiwan pharmacovigilance and ADR reports

Get Taiwan drug recall and withdrawal actions

Get Taiwan regulatory classification and approval status

Get Taiwan drug safety alerts and communications

Search Taiwan drug registration database

Get Thailand pharmacovigilance and ADR reports

Get Thailand drug recall and withdrawal actions

Get Thailand regulatory classification and approval status

Get Thailand drug safety alerts and communications

Search Thailand drug registration database

Momentum L is automatically fed into gyroscopic input.

don't overwhelm core evidence.

with VDAG Reality Gradient.

Triple loop: question the model itself (every 5th analysis).

Reality < 0.20 = testing theater (not executable).

Useful for establishing a baseline or inspecting the default configuration.

structure with per-type counts, duration analysis, and edge breakdown.

Generate Rust code from collected primitives and defeated enemies.

`config.ts` and `index.ts`.

Cargo.toml, source files, and optionally applies a domain plugin.

overlap clusters, and the full graph structure.

Initialize a new Forge session

Mine primitives from a concept

Solve N×M mixed strategy Nash equilibrium via fictitious play.

Analyze an N×M payoff matrix: best responses, dominance, minimax.

Generate forge prompt for a task (now strategy-aware via session harness)

Compute forge quality score: Q = 0.40×prim + 0.25×combat + 0.20×turn + 0.15×survival

Get the primitive reference card

and TODO markers for narrative content.

Forge Schema

to reach a specific ALO or any ALO tagged with a specific KSB reference.

12,000 simulated games in the Primitive Depths genetic algorithm.

Get session summary

Forge System Prompt

Forge Tier

use the vigilance domain IR for cross-referencing.

Domain distance = 1 - weighted overlap of primitive sets across T1/T2/T3 tiers.

Flywheel velocity = 1/avg(failure→fix time).

Signal strength composite S = U × R × T.

Cosine similarity between two feature vectors.

Token-to-operation ratio for LLM efficiency.

Deterministic concept expansion for multi-variant search

distance = 1 - (w1 × T1_overlap + w2 × T2_overlap + w3 × T3_overlap)

velocity = 1 / avg(fix_time - failure_time) in events per millisecond.

FSRS spaced repetition review

Batch fuzzy search

Compute parallel execution levels

Topological sort

This tool is retained for backward compatibility.

Foundation Levenshtein Bounded

SHA-256 hash

For autocorrelation spectra, values are typically in [0, 1].

Lower is better — 0.33 means 3 operations per token.

Parse YAML to JSON

aligned (all operational goals trace to strategic level).

[`InferenceEngine`], and returns the resulting intelligence report.

Render an A3 intelligence report as markdown.

a shippable-artifact readiness flag.

Return the VDAG pipeline ordering for a given variant.

Check anonymization boundary violations for given metrics.

Get the effective policy for a data category under a given mode.

Get properties for a ghost mode.

Scan fields for PII leak patterns.

Scrub PII from a set of fields according to ghost mode policy.

Coverage percentage

Success probability

Whether it's significant (>0.7)

Get battery status of the Galaxy Tab S4

Fetch basic device model and OS version

Execute arbitrary shell commands on the device

Find pure and mixed Nash equilibria for a 2x2 game.

Solve a general N×M game for Nash equilibria using iterative elimination and minimax.

Analyze an N×M payoff matrix: best responses per row/column, dominance analysis, and minimax value.

Compute Nash equilibria for a 2x2 game matrix.

Gcloud Auth List

Gcloud Compute Instances List

Gcloud Config Get

Gcloud Config List

Gcloud Config Set

Gcloud Functions List

Gcloud Iam Service Accounts List

Gcloud Logging Read

Gcloud Projects Describe

Gcloud Projects Get Iam Policy

Gcloud Projects List

Gcloud Run Command

Gcloud Run Services Describe

Gcloud Run Services List

Gcloud Secrets List

Gcloud Secrets Versions Access

Gcloud Storage Buckets List

Gcloud Storage Cp

Gcloud Storage Ls

Compare Gilead Sciences Inc.

Get recent safety labeling changes for Gilead Sciences Inc.

Get Gilead Sciences Inc.

Get Gilead Sciences Inc.

Get Gilead Sciences Inc.

Get Gilead Sciences Inc.

Search Gilead Sciences Inc.

Read the conservation law: ∃ = ∂(×(ς, ∅)) — Existence equals Boundary applied to the Product of State and Nothing.

Run the 8-gate governance deliberation walkthrough.

Read the glossary of terms — Time, Space, Void, State, Persistence, Awareness, Signal, Mutualism

Read a specific law by number (1-8).

Read the eight laws of system homeostasis — the ways a system loses its ability to self-correct, and the restoring forces that bring it back

Read the complete Glass Notebook — the covenant, eight laws, conservation law, glossary, and instructions for agents.

Get known adverse effects with frequency data

Get drug classification — pharmacologic class, mechanism of action, ATC codes, product type, route, and dosage form

Get contraindications, boxed warnings, warnings/precautions, pregnancy, pediatric, and geriatric use information

Get comprehensive drug profile including pharmacology and mechanism

Get drug-drug interactions with mechanism descriptions

Get pharmacokinetics and pharmacodynamics data

Get drug targets (enzymes, transporters, carriers)

Fetch a specific MHRA Drug Safety Update bulletin by its slug (e.g., 'semaglutide-wegovy-ozempic-and-rybelsus-risk-of-non-arteritic-anterior-ischemic-optic-neuropathy-naion').

Get the total count of MHRA Drug Safety Update bulletins (e.g., '861 updates') as an indicator of archive depth and recent activity.

List relative URLs of the most recent MHRA Drug Safety Update bulletins.

List the most recent MHRA Drug Safety Update bulletins.

Assess current CCIM state: NCRR, FIRE progress.

Compute C(d) using the CCIM compound interest equation.

Project capability trajectory over N directives.

Full audit of all 15 commandments

Get information about a commandment

List commandments by category

Verify a single commandment against proof

Full integrity analysis with optional Bloom/domain/threshold configuration.

Convenience KSB response assessment with required Bloom level.

Get domain calibration profile with baseline feature expectations.

Get a specific principle by name

List all available principles

Search principles by keyword

Estimated cost

Alternative options

Audit service value (cost/benefit)

Process a procurement order (GSA)

Fund a research project (NSF grant)

Confidence score

Whether chain is complete

Verdict (Permitted/Flagged)

Persistence level

Recommendation if mismatch

Audit treasury status

Convert signal asymmetry into resources (information arbitrage)

Run all standard folds (sum, count, min, max, mean, variance) in one pass.

Detect outliers using the IQR method.

Compute a specific percentile from values.

Rank items by value, optionally returning only top N.

Parse a JSON tree and perform recursive fold.

No cargo invocations — purely a DAG computation.

once all prior phases are complete.

referenced against the checkpoint file to produce a pending list.

Analyze a graph structure.

Compute betweenness centrality for all nodes

Find connected components (treating edges as undirected)

Construct a graph from various data sources.

Supports 2D and 3D layout, normalizes positions to [-1, 1].

Find shortest path between two nodes (BFS, unweighted)

Compute Betti numbers at a specific filtration value

Compute persistent homology from a distance matrix

Build a Vietoris-Rips complex and return its structure

Compose two confidence values multiplicatively (P(A∧B) = P(A) × P(B)).

Get the full evidence chain with all steps and current confidence.

Start a new evidence chain for a claim.

Add a step to an existing evidence chain (strengthen or weaken).

Gate a value on minimum confidence — returns Ok or rejects with explanation.

Run a grounded skill assessment (Bronze→Diamond compliance).

Wrap a value with confidence and get its band classification.

Append rows to the end of a table.

Read multiple cell ranges in one call.

List all sheet tabs in a Google Spreadsheet.

Get spreadsheet metadata.

Read a cell range from a Google Spreadsheet.

Search for a substring across all cells in a range.

Write values to a cell range.

Compare GSK plc adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for GSK plc products

Get GSK plc clinical trial pipeline — active and recruiting trials by phase

Get GSK plc approved product portfolio — brand names, generics, routes, pharmacologic classes

Get GSK plc product recalls and enforcement actions from FDA

Get GSK plc aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search GSK plc products by keyword — drug name, condition, or therapeutic area

List all registered actuators

Guardian Adversarial Input

Get autonomy-aware ceiling limits for an originator type

Evaluate PV risk context and get recommended responses

Get Guardian event history

Run one iteration of the homeostasis control loop

Inject a test signal into the Guardian system

Classify an entity by its {G, V, R} capabilities

Guardian Reset

List all registered sensors

Compute a point in 3D safety space

Check PHAROS status: existing reports, timer state.

Subscribe to Guardian events (polling snapshot)

Get the conservation law axiom connection for a specific harm type.

Return the complete catalog of all 8 harm types (A-H) with definitions, conservation laws violated, manifestation levels, and examples.

Classify a harm event by three binary attributes: multiplicity (single/multiple), temporal profile (acute/chronic), and response determinism (deterministic/stochastic).

List common harm type combinations that co-occur in clinical practice.

Get the hierarchy manifestation levels for a harm type.

Verify that the 8-type taxonomy is exhaustive — that all 2³=8 combinations of the three binary characteristics are covered.

Measure public health impact of signals

Validate signal efficacy against ground truth (FDA-style validation)

List all available heligrams with their metadata: name, version, twist rate, base pair count, and test count.

Run a heligram by name with input variables.

Run all self-tests for a heligram.

Run self-tests for all heligrams.

Advance one turn on the helix.

Validate ∃ = ∂(×(ς, ∅)) for a system.

Encode a concept through all 5 helix turns.

Compute position on the knowledge helix.

Test whether an action satisfies the mutualism constraint: does it produce ∃ for self WITHOUT reducing ∃ for others?

Compare Jiangsu Hengrui adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Jiangsu Hengrui products

Get Jiangsu Hengrui clinical trial pipeline — active and recruiting trials by phase

Get Jiangsu Hengrui approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Jiangsu Hengrui product recalls and enforcement actions from FDA

Get Jiangsu Hengrui aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Jiangsu Hengrui products by keyword — drug name, condition, or therapeutic area

Classify a tool into Digital Highway tiers I-IV.

Compute destructive factor score for infrastructure stress.

Sort tools into grade-separated batches by highway class.

Merge N parallel tool results through grounded confidence composition.

Check if a tool is being used in its legitimate transportation field.

Plan parallel lanes for a batch of tool calls with grade separation.

Score a tool against the 7 Ideal Tool Qualities.

Run a traffic census on tool usage — reads brain.db telemetry.

Get a specific hormone level

Hormone Modifiers

Hormone Status

Apply a stimulus to the endocrine state

Get Singapore drug registration information

Get HSA safety alerts and Dear Healthcare Professional letters

Get product recall information

Search Singapore ADR database

Get ICH E2B(R3) ICSR data element categories — administrative info, patient data, drug info, reaction/event, narrative structure

Get ICH guideline summary and current step by code

Get MedDRA-related ICH guidelines and terminology references

Get all pharmacovigilance-related guidelines (E2x series)

Get ICH Quality (Q-series) guidelines — stability testing, analytical validation, impurities, QbD, lifecycle management

Get ICH Safety (S-series) guidelines — nonclinical safety pharmacology, carcinogenicity, genotoxicity, reproductive toxicology

Search ICH guidelines by topic, code, or keyword

Get a specific antibody by ID.

List all antibodies with optional filtering.

Propose a new antibody from an observed error/fix pair.

Returns threats found, their severity, and suggested responses.

Useful for learning from build failures.

Immunity Status

Compare Incyte Corporation adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Incyte Corporation products

Get Incyte Corporation clinical trial pipeline — active and recruiting trials by phase

Get Incyte Corporation approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Incyte Corporation product recalls and enforcement actions from FDA

Get Incyte Corporation aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Incyte Corporation products by keyword — drug name, condition, or therapeutic area

Tier: T2-C (N + μ + κ — quantity reduction via mapping and comparison)

Tier: T2-C (N + μ + κ — automatic quantity reduction via clustering)

Tier: T2-P (∂ + ς — boundary configuration + state persistence)

Tier: T2-C (μ + κ + ς — mapping + comparison + state)

Tier: T3 (orchestrates all 6 composites via the Insight trait)

Tier: T2-C (∅ + ∃ + σ — void/existence detection in sequence)

Tier: T2-C (σ + κ + μ — sequence co-occurrence via comparison and mapping)

Tier: T2-C (κ + μ + σ — comparison-filtered query)

Tier: T1 (∅ — Void / clearing state)

Tier: T2-C (ς + N — state query + quantity)

Tier: T3 (full pipeline through unified engine)

Tier: T2-P (λ + ∃ — location + existence)

Tier: T1 (∅ — Void / clearing state)

Tier: T2-C (ς + N + Σ — state query + quantity + aggregation)

Compare Ipsen Biopharmaceuticals adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Ipsen Biopharmaceuticals products

Get Ipsen Biopharmaceuticals clinical trial pipeline — active and recruiting trials by phase

Get Ipsen Biopharmaceuticals approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Ipsen Biopharmaceuticals product recalls and enforcement actions from FDA

Get Ipsen Biopharmaceuticals aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Ipsen Biopharmaceuticals products by keyword — drug name, condition, or therapeutic area

Compare Jazz Pharmaceuticals adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Jazz Pharmaceuticals products

Get Jazz Pharmaceuticals clinical trial pipeline — active and recruiting trials by phase

Get Jazz Pharmaceuticals approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Jazz Pharmaceuticals product recalls and enforcement actions from FDA

Get Jazz Pharmaceuticals aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Jazz Pharmaceuticals products by keyword — drug name, condition, or therapeutic area

Jeopardy Board Control Value

List all Jeopardy categories with their compound multipliers.

List clue dollar values for a given round.

Compute compound velocity from game history.

Compute optimal Daily Double wager.

Jeopardy Optimal Final Wager

Score available board positions by strategic value (Holzhauer strategy).

Determine whether to buzz in on a specific clue.

Compare Johnson & Johnson adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Johnson & Johnson products

Get Johnson & Johnson clinical trial pipeline — active and recruiting trials by phase

Get Johnson & Johnson approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Johnson & Johnson product recalls and enforcement actions from FDA

Get Johnson & Johnson aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Johnson & Johnson products by keyword — drug name, condition, or therapeutic area

List running Jupyter kernels.

List available kernel specifications.

Create a notebook with cells in one call via Jupyter REST API.

Execute all cells in a notebook using `jupyter nbconvert --execute --inplace`.

Reports which stages passed and the overall verdict.

Check PHAROS status: existing reports, timer state.

List the TTS model names accepted by the Kokoro upstream (kokoro, tts-1, tts-1-hd).

List all 67 voice identifiers available on the Kokoro upstream.

Synthesize speech from text using the Kokoro neural TTS model.

probability scores.

Get a specific hormone level

Search documents by query string

Get knowledge engine statistics.

lightest/heaviest, average weight, std dev, class distribution.

weight delta, shared/unique primitives, Jaccard similarity.

Pipeline: Decompose → Weigh → Classify → Analyze → Report

Enthalpy (ΔH) measures weight efficiency: negative = exothermic (more compact).

Learn Assimilate

Learn Extract

Learn Landscape

Learn Normalize

Learn Pipeline

Learn Recall

Learning Daemon Beliefs

Learning Daemon Corrections

Learning Daemon Status

Learning Daemon Trends

Learning Daemon Velocity

height values for terrain mesh rendering.

Add a new lesson with automatic primitive extraction.

Filter lessons by context.

Filter lessons by tag.

Get a lesson by ID.

Search lessons by query string.

Compare Eli Lilly and Company adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Eli Lilly and Company products

Get Eli Lilly and Company clinical trial pipeline — active and recruiting trials by phase

Get Eli Lilly and Company approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Eli Lilly and Company product recalls and enforcement actions from FDA

Get Eli Lilly and Company aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Eli Lilly and Company products by keyword — drug name, condition, or therapeutic area

Tier: T3 (nexcore-caesura × MCP integration)

Tier: T3 (nexcore-caesura × MCP integration)

Tier: T3 (nexcore-caesura × MCP integration)

Vocab List

Look up skills associated with a vocabulary shorthand

Compare Lupin Limited adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Lupin Limited products

Get Lupin Limited clinical trial pipeline — active and recruiting trials by phase

Get Lupin Limited approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Lupin Limited product recalls and enforcement actions from FDA

Get Lupin Limited aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Lupin Limited products by keyword — drug name, condition, or therapeutic area

How big is the this MCP surface?

START HERE.

Get started.

Run a live 3-step demo with real data.

Show a multi-tool chain that demonstrates compound value.

Analyze a Markov chain.

Estimate a Markov chain from observed state sequences.

Compare two crates side-by-side: health scores, LOC ratio, test density diff.

Measure a single crate's health: LOC, test count, entropy, and composite score.

Detect statistically significant metric drift using Welch's t-test on history.

Compute Shannon entropy, max entropy, and redundancy from category counts.

Measure Graph

Compute statistical summary: mean, variance, 95% CI, and linear regression.

Measure Workspace

Get complete MedDRA hierarchy structure — 5 levels (LLT→PT→HLT→HLGT→SOC) with counts, relationships, and multi-axiality

Get MedDRA multi-axiality guidance — how PTs map to multiple SOCs with primary/secondary designation and impact on signal detection

Get Standardised MedDRA Query terms for a safety topic

List all Preferred Terms under a System Organ Class

Get the full MedDRA hierarchy path for a preferred term

Get MedDRA version information, biannual update cycle, and MSSO maintenance organization details

Search MedDRA terms across all hierarchy levels (SOC, HLGT, HLT, PT, LLT)

Extract the breadcrumb path showing the drug's categorization (e.g., Home → Drugs, Herbs and Supplements → Aspirin).

Extract dosing and administration instructions (how should this medicine be used).

Extract the drug name (h1 title) from a MedlinePlus drug monograph page.

Extract why the medication is prescribed (indications, on-label and off-label uses).

Extract special precautions and contraindications for the drug.

List all section headings present on a drug monograph (Why prescribed, Dosing, Precautions, Side effects, etc.).

Get approved New Zealand data sheet for a medicine

Get Prescriber Update bulletin safety articles

Get Medsafe safety communications and alerts

Search CARM adverse reaction reports (Centre for Adverse Reactions Monitoring)

Compare Menarini Group adverse event reporting vs a competitor using PRR from FAERS

Get recent safety labeling changes for Menarini Group products

Get Menarini Group clinical trial pipeline — active and recruiting trials by phase

Get Menarini Group approved product portfolio — brand names, generics, routes, pharmacologic classes

Get Menarini Group product recalls and enforcement actions from FDA

Get Menarini Group aggregate safety profile from FAERS — top adverse reactions, outcomes, products with most reports

Search Menarini Group products by keyword — drug name, condition, or therapeutic area

Compare Merck & Co.

Get recent safety labeling changes for Merck & Co.

Get Merck & Co.

Get Merck & Co.

Get Merck & Co.

Get Merck & Co.

Search Merck & Co.

Check consistency of terms across multiple corpora

Cross-reference a term across MESH, MedDRA, SNOMED, ICH

Enrich a PubMed article with MESH descriptors

Lookup a MESH descriptor by UI or name

Mesh Network Grounding

Tier: T2-C (Cross-domain composite tool)

Tier: T2-C (Cross-domain composite tool)

Tier: T3 (Domain-specific MCP tool)

Search documents by query string

Navigate MESH tree hierarchy

Get Korea pharmacovigilance and ADR reports

Get Korea drug recall and withdrawal actions

Get Korea regulatory classification and approval status

Get Korea drug safety alerts and communications

Search Korea drug registration database

List all available microgram chains with their step sequences.

List all available micrograms with their descriptions and test counts.

Antibody: detects quantity conservation violations (stem-phys Preserve trait).

Antibody: detects cortisol saturation (stem-bio burnout threshold).

Antibody: detects force applied to zero mass (stem-phys F=ma — infinite acceleration).

Antibody: detects hormone level outside [0,1] range (stem-bio invariant).

Antibody: detects enzyme/receptor saturation using Michaelis-Menten model.

Pharmacokinetics: absorption-rate assessment

Pharmacokinetics: accumulation-index assessment

Pharmacokinetics: acetylation assessment

Route flywheel composite health actions to specific remediation strategies.

Classify actuator/sensor ratio: BALANCED (2-5:1), SENSOR_HEAVY (>5:1), ACTUATOR_HEAVY (<2:1)

Adapter: convert evidence_strength from pubmed/literature configmigrams to signal pipeline inputs

Adapter: transforms openFDA FAERS drug_event counts into the input shape needed by PRR/disproportionality computation.

Adapter: convert interaction severity from RxNav/DrugBank configmigrams to signal pipeline inputs

Adapter: transforms DailyMed labeling data (adverse_reactions section) into the input shape needed by expectedness-check microgram.

Adapter: convert risk_tier from DailyMed/recall configmigrams to signal pipeline inputs

Adapter: convert safety_concern from trial SAE triage to seriousness boolean for causality pipeline

Adapter: convert configmigram signal_strength to signal pipeline inputs (signal_detected + synthetic prr)

Determine if drug requires additional monitoring (black triangle symbol) based on regulatory status, market tenure, and conditions.

Clinical safety: administration-route

Domain 2: Classify adverse drug reaction by type (A-F) — mechanism, predictability, dose-dependence, clinical approach.

Domain 3: Grade ADR severity and determine response urgency — maps to CTCAE-style grading with clinical action.

ADR CTCAE grading → escalation routing.

Clinical safety: adr-severity-gate

Determines whether the agent station can handle a query or needs external help

Routes aggregate data assessment to PSUR section assignment and prioritization

PDC: EPA 10 AI Gateway typestate — route phase by current level to next phase and CPA 8 unlock

PDC: Validate EPA10 AI Gateway prerequisites by phase — checks domain levels, exam scores, and project evidence

PVOS alert configuration: validates alert config completeness - requires threshold, notification channel, and valid severity level

Route signal type + value to threshold action using Evans criteria and standard PV thresholds

Algovigilance: triage bias signals by disparity ratio, affected population size, and protected attribute category

Algorithm 8 (CONVERGE): Fixpoint iteration for signal stability.

Algovigilance: classify AI model drift severity from distribution shift metrics (PSI, KS p-value) and observation window

Algorithm 7 (ENERGY): Measures N(→(Δς)) — capacity for change.

Algorithm 10 (LOCATE): Boundary contraction search.

Algorithm 11 (SEAL): Irreversible commitment gate.

Algorithm 12 (SELECT): Differential survival.

Algovigilance: route a classified algo signal to the correct response action based on signal type and severity

Bridge microgram: maps signal-deep-validation outputs to pv-12-algorithm-assessment inputs.

Algorithm 9 (VOID): Detect what's missing.

Ecosystem health gate: detects unresolved field name mismatches that reduce chain connectivity

PDC: Domain 1 (Foundations of PV) behavioral anchors by level — 7 anchors per level, 49 total

PDC: Domain 2 (Clinical ADRs) behavioral anchors by level — 7 anchors per level, 49 total

PDC: Validate behavioral anchor verb against expected competency level (Bloom's taxonomy mapping)

Station operations: annotation-coverage

Classify a confirmed harm signal into its anti-vector strategy.

Signal-to-prescription pipeline: PRR signal detection → anti-vector classification.

Score antibody fleet coverage: LOW (<10), MODERATE (10-20), HIGH (21-30), SATURATED (>30)

Flywheel operational: antibody-gap-finder

Development gate: api-breaking-change

APPE Ch7: Route participant to appropriate PV activity by week and level.

APPE Ch7.2 Domain 2: ADR classification practice — maps reaction characteristics to DoTS/WHO type (A/B/C) with confidence and teaching points.

APPE Ch7.5: AI ethics decision gate — evaluates ethical reasoning about AI in pharmacovigilance across 5 core principles

APPE Ch7.2: Formative and summative assessment gates.

APPE Ch7.4 Domain 14 L2: Adapts PV communication style, language level, and format for clinicians, regulators, patients, executives, and media.

APPE Ch7.6: APPE-to-Fellowship bridge assessment.

APPE Ch7.3: Select appropriate foundational EPA and PV tool chain by week and domain levels.

APPE Ch7.4: Score Foundation-Communication Integration Module (D1+D14) quality.

APPE Ch7.2/7.6: Portfolio completeness tracker — assesses evidence collection progress across domains.

APPE Ch7.6: Behavioral anchor rubric scorer — rates a single observation on the 4-point scale (1=Beginning to 4=Exemplary) across three dimensions

APPE Ch7.2 Domain 2 L1: Temporal pattern recognition for adverse event causality — classifies onset pattern and strengthens/weakens signal via dechallenge/rechallenge evidence.

APPE Ch7: Gate week progression based on behavioral anchor scores across Domains 1-3 and 14.

Pharmacokinetics: area-under-curve assessment

PDC: Route to assessment method based on competency type and level

Development gate: async-complexity-gate

PVOS audit subsystem: routes audit log queries to the correct operation scope (ingest/detect/triage/report/all)

Loop 3 FlywheelVitals: Friction measurement.

Autopilot decision gate for pharmaceutical company monitoring sweep.

Pharmacokinetics: bbb-permeability assessment

Run the benefit-risk assessment chain: weighs therapeutic benefit against safety risk using PRR, Naranjo, NNH, and therapeutic index.

Simple benefit-risk assessment gate determining product balance and regulatory action recommendation.

Academy L2: Given QBRI score and component weights, classify benefit-risk balance and provide regulatory learning feedback.

Benefit-risk decision gate for initial pharmacovigilance assessment: routes to monitoring, management, or mitigation based on benefit/risk scores and unmet need

Compute benefit-risk classification from numeric scores.

Domain 9: Identify bias type and route to appropriate control strategy — selection, information, confounding.

Pharmacokinetics: biliary-excretion assessment

Development gate: binary-size-gate

Clinical safety: bioavailability-gate

Pharmacokinetics: bioavailability-oral assessment

Pharmacokinetics: bioequivalence-gate assessment

Clinical safety: black-box-detector

Clinical safety: blood-brain-barrier

PDC: Map observed behavioral verb category to Bloom taxonomy tier (1-7) for anchor validation

Bone safety classifier: maps skeletal adverse reactions to severity grades for osteonecrosis, fractures, and bone mineral density loss

NexCore boundary threading classifier: routes data stream intersections through boundary hierarchy to determine verification level and analytical precision

Domain 10: Route to benefit-risk assessment framework by complexity, stakeholder needs, and quantitative requirement.

Bradford Hill evidence assessment: signal comparison → dose-response classification → Naranjo causality.

Full 5-criterion Bradford Hill causality assessment: temporal association → signal comparison → dose-response → rechallenge → Naranjo.

Development gate: branch-staleness

Pharmacokinetics: breast-milk-excretion assessment

Closed-loop build management chain: memory-gate → job-scaler → build → cache-prune.

Adaptive build parallelism scaler.

Pre-build memory gate: checks available RAM + free swap against crate build requirements.

Translates build resource metrics (headroom, cache state) into system health status and severity.

Development gate: build-time-gate

Business Value metric BV-01 metric CQ-01

Business Value metric BV-02 metric CQ-01

Business Value metric BV-03 metric CQ-01

Business Value metric BV-04 metric CQ-01

Competency Architecture CA-01 metric PDC-01

Competency Architecture CA-02 metric PDC-01

Competency Architecture CA-03 metric PDC-01

Competency Architecture CA-04 metric PDC-01

Competency Architecture CA-05 metric PDC-01

Competency Architecture CA-06 metric PDC-01

Competency Architecture CA-07 metric PDC-01

Competency Architecture CA-08 metric PDC-01

Competency Architecture CA-09 metric PDC-01

Competency Architecture CA-10 metric PDC-01

Competency Architecture CA-11 metric PDC-01

Competency Architecture CA-12 metric PDC-01

Competency Architecture CA-13 metric PDC-01

Competency Architecture CA-14 metric PDC-01

Competency Architecture CA-15 metric PDC-01

Station operations: cache-hit-ratio

Station operations: canary-gate

Scores a work candidate on 5 dimensions (Atomicity, Permanence, Unblock, Vision, Ground-clearing) and blends with raw urgency for final composite.

Clinical safety: carcinogenicity-tier

Cardiac safety classifier: maps cardiac adverse reactions to severity grades using ICH E14 QT prolongation thresholds and known cardiotoxicity signals

Run the complete case assessment chain: case validity → seriousness classification → causality evidence → regulatory action.

PDC competency assessment: case-coding proficiency classifier

Translates data completeness assessment and CIOMS frequency classification into case quality tier.

PVOS case ingestion: validates case data completeness before ingestion - requires drug, event, and reporter to proceed

PDC competency assessment: case-intake proficiency classifier

PVOS lifecycle router: advances cases through new->triage->assessment->reporting->closed based on state and completion conditions

PDC competency assessment: case-narrative proficiency classifier

PDC competency assessment: case-quality proficiency classifier

Routes ICSR cases through quality assessment into triage.

Evaluates case report completeness against ICSR criteria

Classify case seriousness per ICH E2A criteria.

Transforms case data into standardized signal feed record for PRR computation

PDC competency assessment: case-triage proficiency classifier

ICSR validity checker: enforces 4 minimum criteria per ICH E2B(R3) — reporter, patient, suspect drug, adverse event

Pipeline completo de evaluación de caso clínico en español.

Academy L2: Given a Naranjo score and WHO-UMC categorical inputs, validate dual causality assessment and provide learning feedback on agreement/disagreement between the two methods.

Aggregates temporal association, dechallenge/rechallenge, and Naranjo score into unified causality verdict.

Domain 2: Route to appropriate causality assessment method based on case complexity, data availability, and context.

Bridge: routes causality assessment results to regulatory action with ICH E2B deadlines.

Run an ad-hoc microgram chain by expression.

CPA Integration CI-01 metric PDC-01

CPA Integration CI-02 metric PDC-01

CPA Integration CI-03 metric PDC-01

CPA Integration CI-04 metric PDC-01

CPA Integration CI-05 metric PDC-01

CPA Integration CI-06 metric PDC-01

CPA Integration CI-07 metric PDC-01

CPA Integration CI-08 metric PDC-01

CPA Integration CI-09 metric PDC-01

Regulatory decision: cioms-form-selector

CIOMS frequency classification for adverse reactions per EU SmPC Section 4.8 labeling convention

Regulatory decision: cioms-working-group-router

Evaluates clinical trial maturity and safety data availability.

Development gate: clippy-warning-gate

Positive or gate

Domain 14: Route to communication channel and approach by stakeholder type — regulatory, HCP, patient, internal, partner.

Development gate: commit-message-quality

Loop 1 FlywheelVitals: Community value network health.

Compatibility Predictor: predicts whether two micrograms will be cross-compatible based on empirical matrix findings.

PDC competency assessment: compliance-audit proficiency classifier

PDC competency assessment: compliance-documentation proficiency classifier

Maps case processing outputs to ICH control evidence.

PDC competency assessment: compliance-gap proficiency classifier

PDC competency assessment: compliance-remediation proficiency classifier

PDC competency assessment: compliance-reporting proficiency classifier

Case lifecycle FSM for compliance tracking: RECEIVED -> VALIDATED -> ASSESSED -> REPORTED -> CLOSED.

Flywheel operational: composite-health-aggregator

Assessment confidence level → reporting urgency classification.

Gate on confidence level: HIGH (>=0.8), MEDIUM (>=0.5), LOW (<0.5)

Classify ADR risk level from DailyMed label adverse reactions section.

Station operations: config-diff-impact

Gate drug-drug interaction data from DrugBank get-interactions.

Classify EMA PRAC safety signal output into action priority.

Triage EudraVigilance ICSR volume and ROR signal data

Classify FDA recall severity from accessdata search-recalls output.

Classify FDA safety communication urgency from search output

Station operations: config-freshness-gate

Gate ICH guideline applicability by code series and step

Triage OpenVigil disproportionality output.

Score evidence strength from PubMed search-signal-literature results.

Classify drug interaction severity from RxNav get-interactions output.

Triage clinical trial safety data from compare-trial-arms or get-serious-adverse-events output.

Classify geographic spread of WHO VigiAccess adverse reaction reports.

Route WHO-UMC causality assessment categories to PV actions.

Station operations: connection-pool-health

Validates primitive compositions against the conservation law ∃ = ∂(×(ς, ∅)).

Clinical safety: contraindication-flag

PDC: Full coordinator pipeline — classify task scope, determine HITL level, identify domain, route to CPA agent

Classify correction recency: FRESH (<7d), AGING (7-30d), STALE (>30d)

Flywheel operational: correction-impact-scorer

Station operations: cors-compliance

Data coverage tier classifier: maps a 0-100 coverage percentage to quality tiers for PV data source assessment

CPA capability matrix — given a CPA and level, returns what that CPA can produce at that competency level.

PDC: Return full CPA specification by ID — primary/supporting domains, EPA mappings, AI components, integration modules, agent routing

PDC: Route CPA (1-8) to practice function with capstone detection

Compliance & Quality metric CQ-01

Compliance & Quality metric CQ-02

Compliance & Quality metric CQ-03

Compliance & Quality metric CQ-04

Compliance & Quality metric CQ-05

Compliance & Quality metric CQ-06

Crate architectural fitness classifier.

Development gate: crate-size-gate

Domain 14: Crisis communication routing by severity and timeline — immediate response through recovery.

Pharmacokinetics: crossover-design assessment

Brain backup freshness for trust flywheel: GREEN (<12h), YELLOW (<24h), RED (>24h or missing)

Aggregate 4 crypto micrograms into single GREEN/YELLOW/RED.

Crypto infrastructure health for flywheel homeostasis: GREEN (all ok), YELLOW (degraded), RED (keys missing)

Provenance manifest coverage for insight flywheel: GREEN (all signed), YELLOW (partial), GREY (none yet)

Microgram signature coverage for immunity flywheel: GREEN (100%), YELLOW (partial), RED (none)

Crystalbook 4-Primitive Conservation Check: assess whether a system conserves Existence (∃), Boundary (∂), State (ς), and Nothing (∅).

Crystalbook 8-Law Risk Matrix: assess virtue scores (0-10) for each of the 8 Laws of System Homeostasis.

Crystalbook Full Diagnostic: combines 4-primitive conservation check + law triage into a single diagnostic.

Domain 13: Route to cultural adaptation strategy by dimension — communication, decision-making, authority, safety reporting.

CUSUM (cumulative sum) control chart for sequential signal surveillance.

Classifies Controller::tick verdicts into escalation tiers.

Pharmacokinetics: cyp1a2-substrate assessment

Pharmacokinetics: cyp2c19-substrate assessment

Pharmacokinetics: cyp2c9-substrate assessment

Pharmacokinetics: cyp2d6-substrate assessment

Pharmacokinetics: cyp3a4-substrate assessment

Clinical safety: cytochrome-p450-interaction

Cytokine release syndrome classifier: grades CRS severity per ASTCT 2019 consensus grading

PVOS dashboard: classifies metric health as HEALTHY/WARNING/CRITICAL using standard PV operational thresholds (warn>=70, critical>=90)

Assess data completeness: COMPLETE (>=95%), PARTIAL (>=70%), INSUFFICIENT (<70%)

Domain 7: Assess data quality dimension and route to appropriate validation action — completeness, accuracy, consistency, timeliness, integrity.

Assesses whether sufficient data exists to proceed to the next analysis step in a PV investigation

Classify a PV DD domain risk level from its raw score (0-100).

PV DD GO/NO-GO decision gate.

Classify DD risk multiplier severity from count and type of active multipliers.

Bridge: regulatory deadline + confidence actionability → alert routing.

Dashboard deadline urgency: maps days remaining to traffic level for PV operations center display

Assess dechallenge/rechallenge evidence for drug-event causality.

Classify flywheel score delta between sessions: SURGE (>+10), GROWTH (+3..+10), STABLE (-2..+2), DECLINE (-10..-3), CRASH (<-10)

NexCore denominator confidence scorer: classifies denominator reliability based on data source characteristics, capture rate, and boundary resolution

Development gate: dependency-freshness

Bridge: test verdict deploy flag + quality score ship flag → release approval.

Development gate: deploy-safety-gate

Station operations: deployment-risk-scorer

Dermatologic safety classifier: maps skin adverse reactions to severity grades with SJS/TEN/DRESS as critical signals

Digital Innovation metric DI-01 metric CQ-01

Digital Innovation metric DI-02 metric CQ-01

Digital Innovation metric DI-03 metric CQ-01

Digital Innovation metric DI-04 metric CQ-01

Flywheel operational: dimension-bottleneck-finder

Walt Disney Creative Strategy — evaluate a concept through Dreamer (vision), Realist (execution), and Critic (failure modes) rooms, producing a readiness verdict

Consensus signal classifier across all 4 disproportionality measures (PRR, ROR, IC, EBGM).

Pharmacokinetics: distribution-volume assessment

Station operations: dns-resolution-check

Development gate: doc-density-gate

PDC: Classify competency domain ID (1-15) into thematic group and layer

PDC: Return full domain specification by ID — name, cluster, definition, knowledge count, skill count, AI integration points

Clinical safety: dose-adjustment-hepatic

Clinical safety: dose-adjustment-renal

Pharmacokinetics: dose-escalation assessment

Pharmacokinetics: dose-proportionality assessment

Dose-response relationship classifier: takes low_dose_rate, mid_dose_rate, and high_dose_rate adverse event frequencies and classifies the relationship pattern.

Safety dossier completeness scorer: evaluates FAERS, guideline, and competitor data availability to classify dossier as comprehensive/adequate/minimal/empty with a 0-100 score

PVOS drift alerting: classifies signal drift severity based on PRR change magnitude and time window

Signal drift direction classifier: determines whether a signal metric is rising, falling, or stable based on percentage change

Pharmacokinetics: drug-accumulation assessment

Clinical safety: drug-class-router

Differential drug safety classification: compares two drug profiles by pre-computed signal ratio and PRR ratio to determine which has worse safety profile

Classify whether one drug adverse event rate is meaningfully higher than another using a 1.2x threshold on pre-computed ratio

Pharmacokinetics: drug-food-interaction assessment

Pharmacokinetics: drug-herb-interaction assessment

Determines if multiple data sources are referring to the same drug entity

Clinical safety: drug-interaction-checker

Resolves drug name type and routes to appropriate nomenclature source (RxNorm, WHO-DD, DailyMed)

Safety profile classifier for albuterol.

Safety profile classifier for alendronate.

Safety profile classifier for allopurinol.

Safety profile classifier for alprazolam.

Safety profile classifier for amitriptyline.

Safety profile classifier for amphetamine.

Safety profile classifier for anastrozole.

Safety profile classifier for apixaban.

Safety profile classifier for aripiprazole.

Safety profile classifier for aspirin.

Safety profile classifier for atenolol.

Safety profile classifier for atomoxetine.

Safety profile classifier for baclofen.

Safety profile classifier for benazepril.

Safety profile classifier for bupropion.

Safety profile classifier for buspirone.

Safety profile classifier for carbidopa-levodopa.

Safety profile classifier for carvedilol.

Safety profile classifier for cefdinir.

Safety profile classifier for celecoxib.

Safety profile classifier for cephalexin.

Safety profile classifier for cetirizine.

Safety profile classifier for chlorthalidone.

Safety profile classifier for citalopram.

Safety profile classifier for clindamycin.

Safety profile classifier for clonazepam.

Safety profile classifier for clonidine.

Safety profile classifier for colchicine.

Safety profile classifier for cyclobenzaprine.

Safety profile classifier for dexmethylphenidate.

Safety profile classifier for diazepam.

Safety profile classifier for diclofenac.

Safety profile classifier for digoxin.

Safety profile classifier for diltiazem.

Safety profile classifier for divalproex.

Safety profile classifier for donepezil.

Safety profile classifier for doxazosin.

Safety profile classifier for doxycycline.

Safety profile classifier for duloxetine.

Safety profile classifier for enalapril.

Safety profile classifier for escitalopram.

Safety profile classifier for esomeprazole.

Safety profile classifier for estradiol.

Safety profile classifier for ezetimibe.

Safety profile classifier for famotidine.

Safety profile classifier for fenofibrate.

Safety profile classifier for fexofenadine.

Safety profile classifier for finasteride.

Safety profile classifier for fluconazole.

Safety profile classifier for fluticasone.

Safety profile classifier for furosemide.

Safety profile classifier for gemfibrozil.

Safety profile classifier for glimepiride.

Safety profile classifier for glipizide.

Safety profile classifier for glyburide.

Safety profile classifier for guanfacine.

Safety profile classifier for hydralazine.

Safety profile classifier for hydrocodone.

Safety profile classifier for hydroxychloroquine.

Safety profile classifier for hydroxyzine.

Safety profile classifier for insulin.

Safety profile classifier for irbesartan.

Safety profile classifier for isosorbide-mononitrate.

Safety profile classifier for lamotrigine.

Safety profile classifier for lansoprazole.

Safety profile classifier for latanoprost.

Safety profile classifier for levetiracetam.

Safety profile classifier for levofloxacin.

Safety profile classifier for levothyroxine.

Safety profile classifier for lidocaine.

Safety profile classifier for linagliptin.

Safety profile classifier for loperamide.

Safety profile classifier for loratadine.

Safety profile classifier for lorazepam.

Safety profile classifier for lovastatin.

Safety profile classifier for meloxicam.

Safety profile classifier for memantine.

Safety profile classifier for methylphenidate.

Safety profile classifier for methylprednisolone.

Safety profile classifier for metoclopramide.

Safety profile classifier for metronidazole.

Safety profile classifier for mirtazapine.

Safety profile classifier for montelukast.

Safety profile classifier for morphine.

Safety profile classifier for naproxen.

Safety profile classifier for nifedipine.

Safety profile classifier for nitrofurantoin.

Safety profile classifier for nitroglycerin.

Safety profile classifier for nortriptyline.

Safety profile classifier for olanzapine.

Safety profile classifier for olmesartan.

Safety profile classifier for ondansetron.

Safety profile classifier for oseltamivir.

Safety profile classifier for oxcarbazepine.

Safety profile classifier for oxybutynin.

Safety profile classifier for oxycodone.

Safety profile classifier for pantoprazole.

Safety profile classifier for paroxetine.

Safety profile classifier for penicillin.

Safety profile classifier for phenazopyridine.

Safety profile classifier for phenytoin.

Safety profile classifier for pioglitazone.

Safety profile classifier for potassium-chloride.

Safety profile classifier for pravastatin.

Safety profile classifier for prednisolone.

Safety profile classifier for pregabalin.

Safety profile classifier for promethazine.

Safety profile classifier for propranolol.

Safety profile classifier for quetiapine.

Safety profile classifier for quinapril.

Safety profile classifier for rabeprazole.

Safety profile classifier for ramipril.

Safety profile classifier for ranitidine.

Safety profile classifier for risperidone.

Safety profile classifier for rivaroxaban.

Safety profile classifier for ropinirole.

Safety profile classifier for rosuvastatin.

Safety profile classifier for sildenafil.

Safety profile classifier for sitagliptin.

Safety profile classifier for spironolactone.

Safety profile classifier for sulfamethoxazole-trimethoprim.

Safety profile classifier for sumatriptan.

Safety profile classifier for tamsulosin.

Safety profile classifier for temazepam.

Safety profile classifier for tirzepatide.

Safety profile classifier for tizanidine.

Safety profile classifier for topiramate.

Safety profile classifier for trazodone.

Safety profile classifier for triamcinolone.

Safety profile classifier for valacyclovir.

Safety profile classifier for valsartan.

Safety profile classifier for venlafaxine.

Safety profile classifier for verapamil.

Safety profile classifier for zolpidem.

Classifies overall drug safety profile based on multiple signal dimensions: signal count, serious proportion, fatal count, REMS, and boxed warning status

Domain 5: DSMB recommendation routing — continue, modify, or terminate based on safety/efficacy balance and stopping rules.

Duplicate case detection: classifies case pairs as CONFIRMED/PROBABLE/POSSIBLE/UNLIKELY duplicate based on matching criteria and time window

ICH E2A Section 2: Classify whether an event is an Adverse Event (AE) or Adverse Drug Reaction (ADR) based on causal relationship and temporal association

ICH E2A Section IV: Case completeness scorer — assesses data quality for an expedited safety report across 5 data domains: patient, drug, event, outcome, reporter.

ICH E2A Section 3: Maps causality assessment terminology to standardized categories for regulatory reporting

ICH E2A Section II.D: Concomitant medication causality gate — determines whether a concomitant (non-suspect) drug may be contributing to the adverse event, affecting causality attribution and reporting requirements

ICH E2A Section IV.A: Data collection priority scorer — determines urgency and priority of follow-up data collection based on case characteristics.

ICH E2A Section II.B: Disability/incapacity sub-classification — distinguishes significant persistent disability (seriousness criterion) from temporary impairment (not a criterion)

ICH E2A Section II.C: Determines expectedness of an adverse reaction — listed (expected) vs unlisted (unexpected) in the Reference Safety Information (RSI/IB/SmPC)

ICH E2A Section 4.3: Determines if follow-up information is required for a safety report based on seriousness, outcome, and expectedness

ICH E2A Section II.B: Hospitalization sub-classification — initial (new), prolonged (extension of existing), or elective/planned (not a seriousness criterion).

ICH E2A investigator urgency gate: determines reporting urgency based on SAE awareness and severity